The excellent redox reversibility coupled with outstanding electrical and catalytic properties manifested by SCFM will enable a broad application in energy conversion applications.Wearable and stretchable electronics including various conductors and sensors are featured with their lightweight, high flexibility, and easy integration into functional devices or textiles. However, most flexible electronic materials are still unsatisfactory due to their poor recoverability under large strain. Herein, we fabricated a carbon nanotubes (CNTs) and polyurethane (PU) nanofibers composite helical yarn with electrical conductivity, ultrastretchability, and high stretch sensitivity. The synergy of elastic PU molecules and spring-like microgeometry enable the helical yarn excellent stretchability, while CNTs are stably winding-locked into the yarn through a simple twisting strategy, making good conductivity. By virtue of the interlaced conductive network of CNTs in microlevel and the helical structure in macrolevel, the CNTs/PU helical yarn achieves good recoverability within 900% and maximum tensile elongation up to 1700%. With these features, it can be used as a superelastic and highly stable conductive wire. Moreover, it also can monitor the human motion as a rapid-response strain sensor by adjusting the content of the CNTs simply. This general and low-cost strategy is of great promise for ultrastretchable wearable electronics and multifunctional devices.An Nb-doped TiO2 (Nb-TiO2) film comprising a double structure stacked with a bottom compact layer and top mesoporous layers was synthesized by treating a Ti precursor-coated substrate using a one-step low-temperature steam-annealing (SA) method. The SA-based Nb-TiO2 films possess high crystallinity and conductivity, and that allows better control over the conduction band (CB) of TiO2 for the electron transport layer (ETL) of the perovskite solar cells by the Nb doping level. Optimization of power conversion efficiency (PCE) for the Nb-TiO2-based ETL was combined with the CB level tuning of the mixed-halide perovskite by changing the Br/I ratio. This band offset management enabled to establish the most suitable energy levels between the ETL and the perovskites. This method was applied to reduce the band gap of perovskites to enhance the photocurrent density while maintaining a high open-circuit voltage. As a result, the optimal combination of 5 mol % Nb-TiO2 ETL and 10 mol % Br in the mixed-halide perovskite exhibited high photovoltaic performance for low-temperature device fabrication, achieving a high-yield PCE of 21.3%.Black liquor has caused a tremendous degree of pollution and waste. Exploring the utilization of lignin, which is the major component of black liquor, has become a key factor in dealing with the problem. In this study, lignin derived from black liquor was used as a raw material to prepare carbon materials through different activation methods including KOH, H3PO4, and steam activation. The structure and properties of obtained samples were characterized as well as electrochemical performance when applied on a lithium-oxygen battery. Results of N2 adsorption/desorption showed that all obtained samples possessed high surface area of over 1000 m2/g. XRD, Raman, and XPS also indicated that obtained samples possessed a large defect area and many functional groups. Electrochemical measurements illustrated that all obtained samples exhibited a high discharge capacity over 2.8 mAh/cm2 at 0.02 mA/cm2, while LKAC exhibited the highest discharge capacity of 7.2 mAh/cm2. Cycling tests of all obtained samples indicated a long cycle life of at least 300 cycles. LSAC maintained a 100% retention rate of capacity and stable terminal voltage even after 800th cycle, and its cycling performance was investigated further by XRD and EIS. This study demonstrated excellent performance for lignin-based carbon materials, and provided alternative materials for positive electrode of lithium-oxygen battery.BRD4, a member of the bromodomain and extraterminal domain (BET) family, has emerged as a promising epigenetic target in cancer and inflammatory disorders. All reported BET family ligands bind within the bromodomain acetyl-lysine binding sites and competitively inhibit BET protein interaction with acetylated chromatin. Alternative chemical probes that act orthogonally to the highly conserved acetyl-lysine binding sites may exhibit selectivity within the BET family and avoid recently reported toxicity in clinical trials of BET bromodomain inhibitors. Here, we report the first identification of a ligandable site on a bromodomain outside the acetyl-lysine binding site. Inspired by our computational prediction of hotspots adjacent to nonhomologous cysteine residues within the C-terminal BRD4 bromodomain (BRD4-BD2), we performed a midthroughput mass spectrometry screen to identify cysteine-reactive fragments that covalently and selectively modify BRD4. https://www.selleckchem.com/products/rimiducid-ap1903.html Subsequent mass spectrometry, NMR, and computational docking analyses of electrophilic fragment hits revealed a novel ligandable site near Cys356 that is unique to BRD4 among human bromodomains. This site is orthogonal to the BRD4-BD2 acetyl-lysine binding site as Cys356 modification did not impact binding of the pan-BET bromodomain inhibitor JQ1 in fluorescence polarization assays nor an acetylated histone peptide in AlphaScreen assays. Finally, we tethered our top-performing covalent fragment to JQ1 and performed NanoBRET assays to provide proof of principle that this orthogonal site can be covalently targeted in intact human cells. Overall, we demonstrate the potential of targeting sites orthogonal to bromodomain acetyl-lysine binding sites to develop bivalent and covalent inhibitors that displace BRD4 from chromatin.Solar-steam generation is one of the most promising technologies to mitigate the issue of clean water shortage using sustainable solar energy. Photothermal aerogels, especially the three-dimensional (3D) graphene-based aerogels, have shown unique merits for solar-steam generation, such as lightweight, high flexibility, and superior evaporation rate and energy efficiency. However, 3D aerogels require much more raw materials of graphene, which limits their large-scale applications. In this study, 3D photothermal aerogels composed of reduced graphene oxide (RGO) nanosheets, rice-straw-derived cellulose fibers, and sodium alginate (SA) are prepared for solar-steam generation. The use of rice straw fibers as skeletal support significantly reduces the need for the more expensive RGO by 43.5%, turning the rice straw biomass waste into value-added materials. The integration of rice straw fibers and RGO significantly enhances the flexibility and mechanical stability of the obtained photothermal RGO-SA-cellulose aerogel.